Experiments & Results

Updated 21 May 2020

Porcine Studies

We are working with certified animal testing labs to conduct studies in animal models under IACUC (Institutional Animal Care and Use Committee) approved protocols. A porcine model was chosen as pigs have a respiratory systems that is most similar to human beings. This is essential in order to evaluate system performance and safety. We would like to anonymously acknowledge the laboratory staff for their tireless efforts, and the donors who are enabling this rapid scale-up of animal testing.

Study #1 – 20 March 2020
Study #2 – 24 March 2020
Study #3 – 26 March 2020
Study #4 – 1 April 2020

Benchtop Testing

We conducted testing and experimentation on the benchtop in order to validate system operation under load, investigate calibration of the arm position to volume delivered and understand the actual volume delivered as a function of physiological and breathing circuit parameters.

Bench Testing

Modelling & Waveform Analysis

This work is a model-based and experimental analysis of the flow profiles of the MIT Emergency Ventilator for different patient conditions, incorporating ISO standards.

Modeling & Waveform Analysis


39 Replies to “Experiments & Results”

  1. Saroj Shrestha
    Saroj Shrestha

    We are also working to develop it for Nepal and mass produce it. The crisis might result to some problems but trying best to get it done and working not just for present but future use as well. Hope for the support from around the globe.
    Thank You

  2. Robert Weinberg
    Robert Weinberg

    I think that we should consider thinking outside the box. One of the greatest challenges involves the small number of current working ventilators available versus the anticipated spike in the number of patients requiring ventilator support for respiratory failure.

    Some hospitals have considered having 2 different patients sharing a single ventilator. My concept is to design a central air compessor unit with a number of individual cartridge units which could be “plug and play” inserted into the central unit and arranged radially about it.

    Each separate cartridge would be an autonomous respiratory ventilator – lacking only the power, oxygen and air compressor. Each cartridge could have the appropriate ventilatory settings of inspiratory volume, pressure, frequency dialed in and would run separately from adjacent cartridges which could be independently plugged in to the central compressor, and such an arrangement may be able to provide ventilatory support to up to 5 – 8 patients per unit.

    The challenge in producing such a multi-unit ventilator concerns regulating the ventilatory settings of each cartridge separately while still providing for the full panoply of respiratory settings needed to provide ventilatory support to each patient. This type of multi-unit ventilator has never been designed or built before – to the best of my knowledge – but if we can send a man to the moon, I don’t think that such a multi-unit ventilator with plug-and-play cartridges to provide ventilatory support for 6 – 8 patients simultaneously is impossible or even too challenging to design and build in the next 3 – 4 weeks.

  3. Jaco Fourie
    Jaco Fourie

    Hi. I had a look at the design and was wondering why a mechanical actuator is beging used with a bag. Could a scuba tank with a regulator and solenoid vales not do the same job with less moving parts ?

    • Hairol Aquino
      Hairol Aquino

      The ambú or manual respirator provide a safety Volumen un case of a system error. The maximum Volumen of the ambú, if it would’ve been completely compressed, and the system stop, has low risk to damage the lung of the patient.

  4. Larry Boyer
    Larry Boyer

    I’d love an update on the FDA approval as well.

    Also, does anyone yet have details on the electronics (what microcontroller and what motors, for example) so we can start gearing up for when the full plans are released.

  5. Rune Kongshaug
    Rune Kongshaug

    Hi, all thanks for the comments.
    It seems like 1:2 and even 1:3 breathing ratios may be required. Especially asthma patients may need a longer exhale cycle to avoid asphyxiation (breathing in their own air), thus with more time to exhale. Starting lower pressure and then increase compression by reading the spirometer seems safer as too much pressure too fast can create unintended negative consequences, ok I got it. However, in an environment that is crisis-driven, chaotic, with lack in PPE and in a short supply of qualified staff, we may want to consider pre-settings for infant, young, and adult settings for different lung size, breathing ratios and compression rates. These pre-settings may save time, assure mistake-proofing, and quicker adoption, and thus save more lives. Thoughts?
    Rune

    • N H
      N H

      Because settings vary greatly as a function of each person’s pathology clinicians really need to be able to adjust parameters. We feel that the risk of a device where the decision is automated would be high. A safer solution would be, perhaps, working with your clinical team to create a simple guide to the best recommended settings. And this would need to be updated. We are hearing of I:E of up to 1:4 at 40 BPM with smaller tidal volumes being used with some COVID patients.

  6. keith kropf
    keith kropf

    Has anyone looked at a design using cams and roller followers instead of gears? I think cams would be less prone to wear and changes in torque due to wear, making it more reliable? Also cams are easier and faster to manufacture. They can be designed to give a constant flow rate for a given motor rpm.

    Is anyone working on a design using cams?

  7. Yueh Lee
    Yueh Lee

    E-vent team – do you have access to ASL-5000 for testing? We have tested our unit on an ASL-5000; contact me directly (I also emailed) for my specific concerns if you haven’t. Thanks.

  8. Mustakim ikbal Ahmed
    Mustakim ikbal Ahmed

    we the students of assam engineering college of INDIA had designed a prototype of our own.we are also trying to design an app so as to monitor and regulate the bpm without physical contact……Can we collaborate to make it possible??

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